Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Article Menu
Export Article
More by Authors Links
Article Data
- Views 1070
- Dowloads 138
Original Research
Open AccessOral granular cell tumors: an analysis of 10 new pediatric and adolescent cases and a review of the literature
Oral granular cell tumors: an analysis of 10 new pediatric and adolescent cases and a review of the literature
1Department of Oral and Maxillofacial Pathology, Louisiana State University, School of Dentistry, New Orleans, LA
2Department of Periodontics, Louisiana State University, School of Dentistry, New Orleans, LA
DOI: 10.17796/jcpd.29.1.h310lq3363522441 Vol.29,Issue 1,January 2005 pp.69-74
Published: 01 January 2005
*Corresponding Author(s): Robert B. Brannon E-mail: rbrann@lsuhsc.edu
Abstract
Clinicopathologic studies on the granular cell tumor, a submucosal benign soft-tissue neoplasm, have not addressed the pediatric and adolescent population. This study of patients from birth to 19 years of age describes clinically and microscopically 10 new cases and combines them with 24 well-documented pediatric cases previously published in the English-language literature. Of the 34, patient ages ranged from 3 to 19 years (mean age 14.5 years) with a female-to-male ratio of 3.3 to 1. The most common location was the tongue (50%) and lips (25%). In neoplasms whose epithelial findings were documented microscopically, a reactive pseudoepitheliomatous (pseudocarcinomatous) hyperplasia of the overlying epithelium occurred in 29%. The recurrence rate was less than 10% following conserva-tive surgical excision. This study reveals that an oral granular cell tumor in the first decade of life is an uncommon event and discusses the importance of differentiating between squamous cell carcinoma and granular cell tumor.
Cite and Share
Robert B. Brannon,Payal M. Anand. Oral granular cell tumors: an analysis of 10 new pediatric and adolescent cases and a review of the literature. Journal of Clinical Pediatric Dentistry. 2005. 29(1);69-74.
References
1. Lack EE, Worsham GF, Callihan MD, et al. Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol 13: 301- 316, 1980
2. Apisarnthanarax P. Granular cell tumor. An analysis of 16 cases and review of the literature. J Am Acad Dermatol 5: 171-182, 1981.
3. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral & Maxillofacial Pathology. 2nd ed. Philadelphia, Pa, WB Saunders Co, 465-466, 2002.
4. Collins BM, Jones AC. Multiple granular cell tumors of the oral cavity: report of a case and review of the literature. J Oral Maxillofac Surg 53: 707-711, 1995.
5. Bangle R Jr. A morphological and histochemical study of the granular cell myoblastoma. Cancer 5: 950-965, 1952.
6. Hagen JO, Soule EH, Gores RJ. Granular-cell myoblastoma of the oral cavity. Oral Surg Oral Med Oral Pathol 14: 454-466, 1961.
7. Jones JH. Non-odontogenic oral tumours in children. Br Dent J 119: 439-447, 1965.
8. Pasqual HN, Pasqual RJ. Granular-cell myoblastoma of tongue: report of a case. Oral Surg Oral Med Oral Pathol 24: 592-593, 1967.
9. Whitten JB. The fine structure of an intraoral granular-cell myoblastoma. Oral Surg Oral Med Oral Pathol 26: 202-213, 1968.
10. Bahuth JJ, Lee WW, Acquarelli MJ. Granular cell myoblastoma of the tongue. Arch Otolaryngol 91: 161-165, 1970.
11. Miller AS, Leifer C, Chen S-Y, Harwick RD. Oral granular cell tumors; report of twenty-five cases with electron microscopy. Oral Surg Oral Med Oral Pathol 44: 227-237, 1977.
12. Beemster G, van der Kwast W, Schoen J, van der Waal I. Granular cell tumor of the tongue. Int J Oral Surg 8: 128-132, 1979.
13. Worsaae N, Schwartz O, Pindborg JJ. Follow-up study of 14 oral granular cell tumors. Int J Oral Surg 8: 133-139, 1979.
14. Noonan JD, Horton CE, Old WL, Stokes TL. Granular cell myoblastoma of the head and neck: review of the literature and 10 year experience. Am J Surg 138: 611-614, 1979.
15. Matthews JB, Mason GI. Oral granular cell myoblastoma: an immunohistochemical study. J Oral Pathol 11: 343-352, 1982.
16. Skoglund LA, Holst E. Granular cell tumor on the alveolar ridge in an adult patient: report of a case. Int J Oral Surg 12: 60-63, 1983.
17. Miettinen M, Lehtonen E, Lehtola H, Ekblom P, Lehto VP, Virtanen I. Histogenesis of granular cell tumour—an immunohis-tochemical and ultrastructural study. J Pathol 142: 221-229, 1984.
18. Uhrenholt L, Nielsen M, Christensen L. Granular cell tumor of the uvula. Arch Otorhinolaryngol 243: 293-295, 1986.
19. Truhan AP, Esterly NB. Firm linear plaque on the lip of a child. Granular cell tumor (granular cell myoblastoma, granular cell schwannoma). Arch Dermatol 121: 1199, 1202, 1985
20. Alessi DM, Zimmerman MC. Granular cell tumors of the head and neck. Laryngoscope 98: 810-814, 1988.
21. Garlick JA, Dayan D, Buchner A. A desmoplastic granular cell tumour of the oral cavity: report of a case. Br J Oral Maxillofac Surg 30: 119-121, 1992
22. Rapidis AD, Economidis J, Goumas PD, et al. Tumours of the head and neck in children: a clinico-pathological analysis of 1,007 cases. J Craniomaxillofac Surg 16: 279-286, 1988.
23. Posnick JC. Paediatric craniofacial surgery: historical perspec-tives, recent advancements and refinements. Br J Oral Maxillofac Surg 33: 343-361, 1995.
24. Bhaskar SN. Oral tumors of infancy and childhood: a survey of 293 cases. J Pediatr 63: 195-210, 1963.
25. Maaita JK. Oral tumors in children: a review. J Clin Pediatr Dent 24: 133-135, 2000.
26. Stewart CM, Watson RE, Eversole LR, Fischlschweiger W, Leider AS. Oral granular cell tumors: a clinicopathologic and immunocytochemical study. Oral Surg Oral Med Oral Pathol 65: 427- 435, 1988.
27. Vance SF III, Hudson RP Jr. Granular cell myoblastoma. Clinicopathologic study of forty-two patients. Am J Clin Pathol 52: 208-211, 1969.
Abstracted / indexed in
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.
Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.
JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.
Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.
BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Scopus: CiteScore 1.8 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Submission Turnaround Time
Conferences
Top