Article Data

  • Views 1047
  • Dowloads 152

Original Research

Open Access

Oral-clinical findings and management of epidermolysis bullosa

  • Filiz Namdar Pekiner1,*,
  • Deniz Yücelten2
  • Semih Özbayrak1
  • Emine Ç.Sezen1

1Department of Oral Diagnosis and Radiology, Marmara Unıversity, Faculty of Dentistry, Istanbul,Turkey

2Department of Dermatology, Faculty of Medicine, Marmara Unıversity, Istanbul,Turkey

3,

DOI: 10.17796/jcpd.30.1.y503845545kn78x7 Vol.30,Issue 1,January 2006 pp.59-66

Published: 01 January 2006

*Corresponding Author(s): Filiz Namdar Pekiner E-mail: soezbayrak@superonline.com

Abstract

Epidermolysis bullosa (EB) is a diverse group of disorders that have as a common feature blister for-mation with tissue occuring at variable depths in the skin and/or mucosa. This article reports two cases of EB and review oral- clinical findings of the EB types and approaches for managing the oral- clin-ical manifestations. While systemic treatment remains primarily palliative, it is possible to prevent destruction and subsequent loss of the dentition through appropriate interventions and dental therapy.


Cite and Share

Filiz Namdar Pekiner,Deniz Yücelten,Semih Özbayrak,Emine Ç.Sezen. Oral-clinical findings and management of epidermolysis bullosa. Journal of Clinical Pediatric Dentistry. 2006. 30(1);59-66.

References

1. Marini I., Vecchiet F. Sucralfate: A help during oral management in patients with Epidermolysis bullosa. J Periodontol 72 (5): 691–5, 2001.

2. Hochberg MS., Vazquez-Santiago IA., Sher M. Epidermolysis bullosa, a case report. Oral Surg. Oral Med. Oral Pathol. 75 :54–7, 1993.

3. Bauer EA, Tabas M. A perspective on the role of collagenase in recessive dystrophic epidermolysis bullosa. Arch. Dermatol.124: 734–36, 1988.

4. Coulombe PA, Hutton ME, Lethal A, Hebert A, Paller AS, Fuchs

E. Point mutations in human keratin 14 genes epidermolysis bul-losa simpler patients: genetic and functional analyses. Cell 66: 1301–11, 1991.

5. Eady RAJ. The basement membrane-interface between the epithelium and the dermis:structural features. Arch. Dermatol 124: 709–12, 1988.

6. Fine JD, Bauer EA, Briggaman RA, Carter DM, Eady RAJ, Esterly NB, Holbrook KA, Hurwitz S, Jhonson L, Andrew L, Pearson R, Sybert VP. Revised clinical and laboratory criteria for subtypes of inherited epidermolysis bullosa. J. Am. Acad. Dermatol. A consensus report by the Subcommitee on Diagnosis and Classification of the National Epidermolysis Bullosa Registry 24: 119–35, 1991.

7. Fine JD. The skin basement membrane zone. Adv. Dermatol 2: 283–303, 1987.

8. Tidman MJ., Eady RAJ. Evaluation of anchoring fibrils and other components of the dermal-epidermal junction in dystroph-ic epidermolysis by a quantitative ultrastructural technique. J. Invest Dermatol. 84: 374–77, 1985.

9. Tidman MJ, Eady RAJ. Hemidesmosome heterogeneity in junc-tional epidermolysis bullosa revealed by morphometric analysis. J Invest Dermatol 86: 51–56, 1986.

10. Mckenna K., HUghes A., Bingham E., Nevin N. Linkage of epi-dermolysis bullosa to keratin gene loci. J.Med Genet 29: 568–70, 1992.

11. Ryynanen M., Knowlton RG., Uitto J. Mapping of epidermolysis bullosa simplex patients mutation to chromosome12. Am J Hum Genet 49: 978–84, 1991.

12. Ryynanen M., Ryynanen J., Solberg S., Iozzo RV., Knowlton RG., Uitto J. Genetic linkage of type VII collagen (COL7A1) to domi-tant dystrophic epidermolysis bullosa in families with abnormal anchoring fibrils. J Clin Invest 89: 974–80, 1992.

13. Camm HJ, Gray SE, Mayes TC. Combined medical and dental treatment of an epidermolysis bullosa patient. Spec Care Dent 11: 148–50, 1991.

14. Lanier PA., Posnick WR., Donly KJ. Epidermolysis bullosa-den-tal management and anesthetic considerations:case report. Pediatr Dent 12: 246–49, 1990.

15. Wright TJ. Comprehensive dental care and general anesthetic management of hereditary epidermolysis bullosa: a review of fourteen cases. Oral Surg Oral Med Oral Pathol 70: 573–78, 1990.

16. Holbrook KA. Extracutaneous epithelial involvement in inherit-ed epidermolysis bullosa. Arch Dermatol 124: 726–31, 1988.

17. El-Khashab MM, Abdel-Aziz AM. Oral aspects in epidermolysis bullosa and sistemic scleroderma. Egyptian Dental J 24: 123–8, 1978.

18. Gazi MI. Epidermolysis bullosa simplex. Quintesence Int. 18: 655–8, 1987.

19. Wright J, Fine JD, Jhonson L Oral soft tissues in hereditary epi-dermolysis bullosa. Oral Surg. Oral Med. Oral Pathol 70: 573–78, 1990.

20. Wright J, Capps J, Fine JD, Johnson L. Dental caries variation in the different epidermolysis bullosa disease. J Dent Res 68: 416, 1989.

21. Nowak AJ. Oropharyngeal lesions and their management in epi-dermolysis bullosa. Arch Dermatol 124: 742–45, 1988.

22. Wright J, Childers NK, Evans KL, Johnson L, Fine JD. Salivary function of persons with hereditary epidermolysis bullosa. Oral Surg Oral Med Oral Pathol 71:554–59, 1991.

23. Fine JD, Johnson L, Wright J. Inherited blistering disease of the skin. Pediatrics 18: 175–87, 1991.

24. Fine JD, Tamura T, Jhonson L. Blood vitamine and trace metal levels in epidermolysis bullosa.Arch Dermatol 125: 374–79, 1989.

25. Gruskay DM. Nutritional management in the child with epider-molysis bullosa. Arch Dermatol 124: 760–61, 1988.

26. Greider JL., Flatt AE. Surgical restorations of hand in epider-molysis bullosa. Arch Dermatol 124: 765–67, 1988.

27. Wright JT. Epidermolysis bullosa: dental and anesthetic manage-ment of two cases. Oral Surg Oral Med Oral Pathol 57:155–7, 1984.

28. Carrol DL., Stephan MJ., Hays GL. Epidermolysis bullosa: review and report of case. J.A.D.A. 107: 749–51, 1983.

29. Wright JT. Epidermolysis bullosa: dental and anesthetic consid-erations- case report. Pediatr Dent 12:246–9, 1990.

30. Wright JT. Comprehensive dental care and general anesthetic management of hereditary epidermolysis bullosa. Oral Surg Oral Med Oral Pathol 70:573–8, 1990.

31. Wright JT., Fine JD., Johnson L. Hereditary epidermolysis bul-losa: oral manifestations and dental management. Pediatr Dent 15:242–47, 1993.

32. Reddy ARR., Wong DHW. Epidermolysis bullosa: a review of anaesthetic problems and case reports. Can Anaesth Soc J 19:536–48, 1972.

33. Marshall BE.A comment on epidermolysis bullosa and its anaes-thetic management for dental operations: case report. Br J Anaesth 35: 724–27, 1963.

34. Wright JT., Fine JD., Johnson L. Dental caries risk in hereditary epidermolysis bullosa. Pediatr. Dent. 16: 427–32, 1994.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Scopus: CiteScore 1.8 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Submission Turnaround Time

Conferences

Top