Article Data

  • Views 1031
  • Dowloads 141

Original Research

Open Access

pH of Medicated Syrups–Does It Really Matter? – An in-vitro Study: Part-II

  • KL Girish Babu1,*,
  • Kavita Rai2
  • Amitha M Hegde2

1Department of Pedodontics, The Oxford Dental College, Hospital and Research Centre, Hosur Road, Bangalore-68, Karnataka, India

2Department of Pedodontics and Preventive Dentistry, A.B. Shetty Memorial Institute of Dental Sciences, Deralakatta, Mangalore, Karnataka, India

DOI: 10.17796/jcpd.33.2.q5280t3744827v0h Vol.33,Issue 2,March 2009 pp.137-142

Published: 01 March 2009

*Corresponding Author(s): KL Girish Babu E-mail: drgirish77@yahoo.com amipedo@yahoo.co.in

Abstract

The aim of the present in vitro study was to quantify the endogenous erosive potential of the various pediatric liquid medicaments by measuring the calcium dissolution of primary enamel after immersing it for different time intervals (1min, 10 min and 8 hours) using atomic absorption spectrometer (AAS). The eight commonly used pediatric liquid medicaments which were selected had definitive endogenous calcium dissolution potential. All the medicaments showed calcium dissolution of primary enamel at alkaline pH and near neutral pH. The calcium dissolution potential of pediatric liquid medicaments when compared with their respective pH showed no statistically significant correlation. In conclusion, there was evidence of calcium dissolution from all the pediatric liquid medicaments.

Keywords

Erosion, Pediatric liquid medicaments, Chelating agents, pH, Calcium dissolution

Cite and Share

KL Girish Babu,Kavita Rai,Amitha M Hegde. pH of Medicated Syrups–Does It Really Matter? – An in-vitro Study: Part-II. Journal of Clinical Pediatric Dentistry. 2009. 33(2);137-142.

References

1. Allan DN. Dental erosion from vomiting. A case report.Br Dent J, 126: 311–2, 1969.

2. Bagarlett D, Smith B. Clinical investigations of gastro-esophageal reflux: Part 1. Dent update, 23: 205–8, 1996.

3. Zazarchik DA, Fuller SJ. Dental erosion-predominant oral lesion in gastro esophageal reflux disease. Am J Gastroenterol, 95(8 Suppl): 553–8, 2000.

4. Valena V, Young WG. Dental erosion patterns from intrinsic acid regur-gitation and Vomiting. Aust Dent J, 47: 106–15, 2002.

5. Bassiouny MA, Pollack RL. Esthetic management of perimolyses with porcelain laminate veneers. J Am Dent Assoc, 115: 412–7, 1987.

6. Edwell HL, Dent CD, Sharp JG. Bulimia- induced dental erosion in a male patient. Quitessence Int, 30: 135–8,1999.

7. Eccles,JD, Jenkins WG. Dental Erosion and Diet. J Dent, 2: 153–9, 1974.

8. Harrison JL, Roeder LB. Dental Erosion caused by cola beverages. Gen Dent, 39: 23–24, 1991.

9. Meuraman JH, Vesterinen M, Wine alcohol and oral health, with spe-cial emphasis on dental erosion. Quint Int, 31: 729–33, 2000.

10. AL Dlaign YH, Shaw L, Smith AJ. Dental erosion in a group of British 14year old school children. Part III: Influence of oral hygiene practices. R Dent J, 192: 526–30, 2002.

11. AL-Majed I, Maguire A, Murray JJ. Risk factors for dental erosion in

5- 6 year old and 12-14 year old boys in Saudi Arabia. Community Dent Oral Epidemiol, 30: 38–46, 2002.

12. AL –Malik MI, Holt RD, Bedi R. Erosion, caries and rampant caries in preschool children in Jeddah, Saudi Arabia .Community Dent Oral Epi-demiol, 30: 16–23, 2002.

13. AL–Malik MI, Holt RD, Bedi R. Clinical and photographic assess-ments of erosion in 2-5 year old children in Saudi Arabia. Comm Dent Health, 18: 232–5, 2001.

14. Ganss C, Klimek J, Gieses K. Dental erosion in children and adoles-cents –across-sectional and longitudinal investigation using study mod-els. Community Dent Oral Epidemiol 29: 264–71, 2001.

15. Bassiouny A, Zarrinnia. Dental erosion: a complication of Pervasive Developmental Disorder. J Clin Ped Dent, 28: 273–278, 2004.

16. Nunn JH Prevalence of dental erosion and the implications for oral health. Eur J Oral Sci, 104: 156–162, 1983.

17. Sullivan RE, Kramer WS. Iatrogenic erosion of teeth. J Dent Child, 50: 192–196, 1983.

18. Giunta JL. Dental erosion resulting from chewable vitamin C tablets. J Am Dent Ass, 107: 253–255, 1983.

19. Shaw L, Al-Dlaigan YH, Smith A. Childhood asthma and dental ero-sion. J Dent Child, 67: 102–106, 2000.

20. James PMC, Parfitt GJ. Local effects of certain medicaments on the teeth. Br Med J, 4848:1252–1253, 1953.

21. Meurman JH, Murtomaa H. Effect of effervescent vitamin C prepara-tions on bovine teeth and on some clinical and salivary parameters in man. Scand J Dent Res, 94: 491–499, 1986.

22. Bhatti SA, Walsh TF, Douglas CWI. Ethanol and pH levels of propri-etary mouth rinses. Comm Dent Health, 11: 71–74, 1994.

23. Kilpatrick NM, Awand H, Wilcken B, Christodoulou J. The implica-tions of phenyketonuria on oral health. Ped Dent, 21: 433–437, 1999.

24. Ng KFS. The acid content of oral liquid and effervescent tablet formu-lations-implications for dental care in children. BPharm dissertation. Bradford: University of Bradford,1998.

25. Nunn JH, Ng KFS, Sharkey I, Coulthard M. The dental implications of chronic use of acidic medicines in medically compromised children. Pharm World Sci, 23: 118–119:2001.

26. Johansson AK, Sorvari R, Birkhed D, Meurman JH. Dental erosion in deciduous teeth—an in vivo & in vitro study; J Dent, (5): 333–40, 2001.

27. Erickson PK. Estimation of the Caries- related risk associated with infant formula. Ped Dent, 20(7): 395–4, 1998.

28. Ten Cate JM. What dental diseases are we facing in the new millen-nium? Caries Res, 35: 2–5, 2001.

29. Linnett V, Seow WK. Dental erosion in children: a literature review. Ped Dent, 23: 37–43, 2001.

30. Costal CC, Almeida ICS, Costa Filho LC. Erosive effect of antihista-mine-containing syrup on primary enamel and its reduction by fluoride dentifrice. Int J Ped Dent, 16: 174–180, 2006.

31. McDonald JL, Stookey GK. Laboratory studies concerning the effect of acid-containing beverages on enamel dissolution and experimental dental caries. J Dent Res, 52: 211–216, 1973.

32. Mc Clure F.J, Ruzicka S.J. The destructive effect of citrate versus lac-tate ions on rats molar tooth surfaces, in vivo. J. Dent Res, 25: 1, 1946.

33. Cole AS, Eastoe JE. Biochemistry and Oral Biology. 2nd edn. Butter-worth and Co (publishers) Ltd, 12–13. 1988.

34. William G. Shafer. A Textbook of Oral Pathology, 4th edn. W.B. Saun-ders Company, 417, 1993.

35. Martin JJ, Isenberg HD, Schatz V. Chelation, or metal binding, as a new approach to the problem of dental caries. Revista Mensual de ciencias Exactas (Madrid), 14; 311–317, 1954.

36. Onose H, Sandham HJ. pH changes during culture of human dental plaque streptococci on mitis-salivarius agar. Arch oral Biol, 21: 291–296, 1976.

37. Morch T, Punwani I, Greve E. The possible role of complex forming substances in the decalcification of the caries process. Caries Res, 5: 135–143, 1971.

38. Anderson P, Hector MP & Rampersad MA. Critical pH in resting & stimulated whole saliva in groups of children & adults. Int. J. Ped Dent, 11: 266–273, 2001.

39. Kenny JD, Somaya P. Sugar load of oral liquid medications on chroni-cally all children. Journal scientific; 55: 43–46, 1989.

40. Marthaki E, MA Pollard, MEJ Curzon .The effect of sucrose in medi-cines on plaque pH. Int J Paed Dent. 5: 231–235, 1995.

41. KL Girish Babu, K Rai, AM Hedge. Pediatric liquid medicaments. Do they erode the teeth? An in vitro study-Part 1. J Clin Ped Dent, 32(3): 189–94, 2007.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Scopus: CiteScore 1.8 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Submission Turnaround Time

Conferences

Top