Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Article Menu
Export Article
More by Authors Links
Article Data
- Views 1276
- Dowloads 164
Original Research
Open AccessCleft Lip and Palate: Association with Other Congenital Malformations
Cleft Lip and Palate: Association with Other Congenital Malformations
- Soraya Beriaghi1,*,
- Sandra L Myers2
- Scott A Jensen3
- Shanti Kaimal2
- Cynthia M Chan4
- G Bradley Schaefer5
1Division of Pediatric Dentistry School of Dentistry, University of Minnesota, Minneapolis, MN
2NIDCR’s TMJ Implant Registry and Repository, School of Dentistry University of Minnesota, Minneapolis, MN
3Private Practice, American Fork, UT, USA
4Department of Hospital Dentistry, University of Nebraska Medical Center, Omaha, NE, USA
5University of Arkansas for Medical Sciences, Division of Medical Genetics and Department of Pediatrics, Little Rock, AR USA
*Corresponding Author(s): Soraya Beriaghi E-mail: beira001@umn.edu
Abstract
Orofacial clefts are frequently associated with other congenital malformations. Studies vary in incidence and types of anomalies. Objective: To evaluate associated malformations in orofacial cleft patients at a major research hospital. Study Design: Medical records of 1127 patients, in the Cleft Palate / Craniofacial Clinic, Boys Town National Research Hospital, from January 1980 through February 2000 were reviewed. Patients were divided into two categories: 1) cleft palate only (CP), and 2) cleft lip, with or without cleft palate (CL±P). Further categorization included location and type, if any, of other congenital malformations.Results: 47.2% of patients had CP and 52.8% had CL±P. 32.2% of all cleft patients had associated congenital malformations. The orofacial region was the most common site, followed by cardiovascular, central nervous, and skeletal systems. Congenital malformations were more common in CP (38.7%), than CL±P(26.4%). Of malformations diagnosed, 63.1% were chromosomal/syndromic anomalies while 36.9% were non-chromosomal/syndromic. Conclusions: Recognition of the spectrum of congenital malformations,associated with orofacial clefting, is essential for further diagnostic testing and in some cases genetic counseling.
Keywords
congenital malformations, anomalies, orofacial clefts, syndromes
Cite and Share
Soraya Beriaghi,Sandra L Myers,Scott A Jensen,Shanti Kaimal,Cynthia M Chan,G Bradley Schaefer. Cleft Lip and Palate: Association with Other Congenital Malformations. Journal of Clinical Pediatric Dentistry. 2009. 33(3);207-210.
References
1. Croen LA, Shaw GM, Wasserman CR, et al. Racial and ethnic varia-tions in the prevalence of orofacial clefts in California, 1983–1992. Am J Med Genet 79: 42–7, 1998.
2. Gorlin R, Cohen M, Hennekam R. Syndromes of the head and neck. New York, Oxford University Press, 2001.
3. Forrester M, Merz R. Descriptive epidemiology of oral clefts in a mul-tiethnic population, Hawaii, 1986–2000. Cleft Palate Craniofac J, 41: 622–628, 2004.
4. Fogh-Andersen P. Inheritance of hare lip and cleft palate. Copenhagen, Arnold Busck, Nordisk Forlag, 1942.
5. Herrmann J, France T, Spranger J, et al. The Stickler syndrome (hered-itary arthroophthalmopathy). Birth Defects Orig Artic Ser, 11: 76–103, 1975.
6. Ghassibe M, Bayet B, Revencu N, et al. Orofacial clefting: update on the role of genetics. B-Ent 2 Suppl. 4: 20–4, 2006.
7. Abyholm FE. Cleft lip and palate in a Norwegian population. II. A numerical study of 1555 CLP-patients admitted for surgical treatment 1954-75. Scand J Plast Reconstr Surg, 12: 35–43, 1978.
8. Milerad J, Larson O, Ph DD, et al. Associated malformations in infants with cleft lip and palate: a prospective, population-based study. Pedi-atrics, 100: 180–6, 1997.
9. Shaw G, Carmichael SL, Yang W, et al. Congenital malformations in births with orofacial clefts among 3.6 million California births 1983–1997. American Journal of Medical Genetics, 125A: 250–256, 2004.
10. Pashayan HM. What else to look for in a child born with a cleft of the lip and/or palate. Cleft Palate J, 20: 54–82, 1983.
11. Wyszynski DF, Sarkozi A, Czeizel AE. Oral clefts with associated anomalies: methodological issues. Cleft Palate Craniofac J, 43: 1–6, 2006.
12. Fraser FC. The genetics of cleft lip and cleft palate. Am J Hum Genet, 22: 336–52, 1970.
13. Shprintzen RJ, Siegel-Sadewitz VL, Amato J, et al. Anomalies associ-ated with cleft lip, cleft palate, or both. Am J Med Genet, 20: 585–95, 1985.
14. Sarkozi A, Wyszynski DF, Czeizel AE. Oral clefts with associated anomalies: findings in the Hungarian Congenital Abnormality Reg-istry. BMC Oral Health, 5: 4, 2005.
15. van der Veen FJ, van Hagen JM, Berkhof J, et al. Regional underre-porting of associated congenital anomalies in cleft patients in the Netherlands. Cleft Palate Craniofac J, 43: 710–4, 2006.
16. Vallino-Napoli LD, Riley MM, Halliday JL. An epidemiologic study of orofacial clefts with other birth defects in Victoria, Australia. Cleft Palate Craniofac J, 43: 571–6, 2006.
17. Rustemeyer J, Gunther L, Krause HR, et al. [Associated anomalies in lip-maxillopalatal clefts]. Mund Kiefer Gesichtschir, 4: 274–7, 2000.
18. Calzolari E, Pierini A, Astolfi G, et al. Associated anomalies in multi-malformed infants with cleft lip and palate: An epidemiologic study of nearly 6 million births in 23 EUROCAT registries. Am J Med Genet A, 143: 528–37, 2007.
19. Stark R. Cleft palate: a multidiscipline approach. New York, Harper & Row, 1968.
20. Lilius GP. Clefts with associated anomalies and syndromes in Finland. Scand J Plast Reconstr Surg Hand Surg, 26: 185–96, 1992.
21. Stoll C, Alembik Y, Dott B, et al: Associated malformations in cases with oral clefts. Cleft Palate Craniofac J, 37: 41–7, 2000.
Abstracted / indexed in
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.
Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.
JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.
Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.
BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Scopus: CiteScore 1.8 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Submission Turnaround Time
Conferences
Top