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Original Research
Open AccessCleft Lip and Palate: Association with Other Congenital Malformations
Cleft Lip and Palate: Association with Other Congenital Malformations
- Soraya Beriaghi1,*,
- Sandra L Myers2
- Scott A Jensen3
- Shanti Kaimal2
- Cynthia M Chan4
- G Bradley Schaefer5
1Division of Pediatric Dentistry School of Dentistry, University of Minnesota, Minneapolis, MN
2NIDCR’s TMJ Implant Registry and Repository, School of Dentistry University of Minnesota, Minneapolis, MN
3Private Practice, American Fork, UT, USA
4Department of Hospital Dentistry, University of Nebraska Medical Center, Omaha, NE, USA
5University of Arkansas for Medical Sciences, Division of Medical Genetics and Department of Pediatrics, Little Rock, AR USA
*Corresponding Author(s): Soraya Beriaghi E-mail: beira001@umn.edu
Abstract
Orofacial clefts are frequently associated with other congenital malformations. Studies vary in incidence and types of anomalies. Objective: To evaluate associated malformations in orofacial cleft patients at a major research hospital. Study Design: Medical records of 1127 patients, in the Cleft Palate / Craniofacial Clinic, Boys Town National Research Hospital, from January 1980 through February 2000 were reviewed. Patients were divided into two categories: 1) cleft palate only (CP), and 2) cleft lip, with or without cleft palate (CL±P). Further categorization included location and type, if any, of other congenital malformations.Results: 47.2% of patients had CP and 52.8% had CL±P. 32.2% of all cleft patients had associated congenital malformations. The orofacial region was the most common site, followed by cardiovascular, central nervous, and skeletal systems. Congenital malformations were more common in CP (38.7%), than CL±P(26.4%). Of malformations diagnosed, 63.1% were chromosomal/syndromic anomalies while 36.9% were non-chromosomal/syndromic. Conclusions: Recognition of the spectrum of congenital malformations,associated with orofacial clefting, is essential for further diagnostic testing and in some cases genetic counseling.
Keywords
congenital malformations, anomalies, orofacial clefts, syndromes
Cite and Share
Soraya Beriaghi,Sandra L Myers,Scott A Jensen,Shanti Kaimal,Cynthia M Chan,G Bradley Schaefer. Cleft Lip and Palate: Association with Other Congenital Malformations. Journal of Clinical Pediatric Dentistry. 2009. 33(3);207-210.
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