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Banking Stem Cells from Human Exfoliated Deciduous Teeth (SHED): Saving for the Future
1Department of Conservative Dentistry and Endodontics, K.D. Dental College and Hospital, Mathura, INDIA
2Department of Oral & Maxillofacial Prosthodontics and Dental Implants, K.D. Dental College and Hospital, Mathura, INDIA
3Department of Pediatric Dentistry Dean, Director and Principal, K.D. Dental College and Hospital, Mathura, INDIA
DOI: 10.17796/jcpd.33.4.y887672r0j703654 Vol.33,Issue 4,July 2009 pp.289-294
Published: 01 July 2009
*Corresponding Author(s): Vipin Arora E-mail: vipin_endodontist@yahoo.co.in
Tooth derived cells are readily accessible and provide an easy and minimally invasive way to obtain and store stem cells for future use. Banking ones own tooth-derived stem cells is a reasonable and simple alternative to harvesting stem cells from other tissues.
Obtaining stem cells from human exfoliated deciduous teeth (SHED) is simple and convenient, with little or no trauma. Every child loses primary teeth, which creates the perfect opportunity to recover and store this convenient source of stem cells – should they be needed to treat future injuries or ailments and presents a far better alternative to simply discarding the teeth or storing them as mementos from the past. Furthermore,using ones own stem cells poses few, if any, risks for developing immune reactions or rejection following transplantation and also eliminates the potential of contracting disease from donor cells. Stem cells can also be recovered from developing wisdom teeth and permanent teeth. Individuals have different opportunities at different stages of their life to bank these valuable cells. It is best to recover stem cells when a child is young and healthy and the cells are strong and proliferative.
The purpose of this review is to discuss the present scenario as well as the technical details of tooth banking as related to SHED cells.
deciduous teeth, SHED, banking
Vipin Arora,Pooja Arora,AK Munshi. Banking Stem Cells from Human Exfoliated Deciduous Teeth (SHED): Saving for the Future. Journal of Clinical Pediatric Dentistry. 2009. 33(4);289-294.
1. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A, 100(10): 5807–12, 2003.
2. de Mendonça Costa A, Bueno DF, Martins MT, Kerkis I, Kerkis A, Fan-ganiello RD, Cerruti H, Alonso N, Passos-Bueno MR.Reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells. J Craniofac Surg, 19(1): 204–10, 2008.
3. Seo BM, Sonoyama W, Yamaza T, Coppe C, Kikuiri T, Akiyama K, Lee JS, Shi S. SHED repair critical-size calvarial defects in mice. Oral Dis, 14(5): 428–34, 2008.
4. Balwant Rai. Stem Cells from human exfoliated deciduous teeth and SHED Bank: A Mini View. The Internet Journal of Bioengineering, 2(2): 2007
5. Irina Kerkis, Carlos E Ambrosio, Alexandre Kerkis, Daniele S Martins, Eder Zucconi, Simone AS Fonseca, Rosa M Cabral, Carlos MC Maran-duba, Thais P Gaiad, Adriana C Morini, Natassia M Vieira, Marina P Brolio, Osvaldo A Sant’Anna, Maria A Miglino, and Mayana Zatz Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic? J Transl Med, 6: 35, 2008.
6. Gandia C, Armiñan A, García-Verdugo JM, Lledó E, Ruiz A, Miñana MD, Sanchez-Torrijos J, Payá R, Mirabet V, Carbonell-Uberos F, Llop M, Montero JA, Sepúlveda P Human dental pulp stem cells improve left ventricular function, induce angiogenesis, and reduce infarct size in rats with acute myocardial infarction. Stem Cells, 26(3): 638–45, 2007.
7. Arthur A, Rychkov G, Shi S, Koblar SA, Gronthos S. Adult human den-tal pulp stem cells differentiate toward functionally active neurons under appropriate environmental cues. Stem Cells, 26(7): 1787–95, 2008.
8. Jeremy J. Mao. Stem Cells and the Future of Dental Care. New York State Dental Journal, 74(2): 21–24, 2008.
9. Jay B. Reznick. Continuing Education: Stem Cells: Emerging Medical and Dental Therapies for the Dental Professional. Dentaltown maga-zine, Oct: 42–53, 2008.
10. Abbas, Diakonov I., Sharpe P. Neural Crest Origin of Dental Stem Cells. Pan European Federation of the International Association for Dental Research (PEF IADR). Seq #96 - Oral Stem Cells: Abs, 0917, 2008
11. Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S.The effi-cacy of mesenchymal stem cells to regenerate and repair dental struc-tures. Orthod Craniofac Res, 8(3): 191–9, 2005.
12. Perry BC, Zhou D, Wu X, Yang FC, Byers MA, Chu TM, Hockema JJ, Woods EJ, Goebel WS. Collection, cryopreservation, and characteriza-tion of human dental pulp-derived mesenchymal stem cells for banking and clinical use. Tissue Eng Part C Methods, 14(2): 149–56, 2008.
13. Cordeiro MM, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S, Smith AJ, Nör JE. Dental pulp tissue engineering with stem cells from exfo-liated deciduous teeth. J Endod, 34(8): 962–9, 2008.
14. Mao JJ, Giannobile WV, Helms JA, Hollister SJ, Krebsbach PH, Lon-gaker MT, Shi S. Craniofacial tissue engineering by stem cells. J Dent Res, 85(11): 966–79, 2006.
15. Freshney Ian R et al. Culture of human stem cells. Chapter 8: 187–207, 2007.
16. Oh YH, Che ZM, Hong JC, Lee EJ, Lee SJ, Kim J. Cryopreservation of human teeth for future organization of a tooth bank—a preliminary study. Cryobiology, 51(3): 322–9, Epub 2005.
17. Politis C, Vrielinck L, Schepers S, Lambrichts I.Cryopreservation of teeth. Organizational aspects of a tissue bank for tooth tissues. Acta Stomatol Belg, 92(4): 149–54, 1995.
18. Suchánek J, Soukup T, Ivancaková R, Karbanová J, Hubková V, Pytlík R, Kucerová L. Human dental pulp stem cells—isolation and long term cultivation. Acta Medica (Hradec Kralove), 50(3): 195–201, 2007.
19. Zhang W, Walboomers XF, Shi S, Fan M, Jansen JA. Multilineage dif-ferentiation potential of stem cells derived from human dental pulp after cryopreservation. Tissue Eng, 12(10): 2813–23, 2006.
20. Papaccio G, Graziano A, d’Aquino R, Graziano MF, Pirozzi G, Men-ditti D, De Rosa A, Carinci F, Laino G. Long-term cryopreservation of dental pulp stem cells (SBP-DPSCs) and their differentiated osteoblasts: a cell source for tissue repair. J Cell Physiol, 208(2): 319–25, 2006.
21. TT-450—Stem Cells and Teeth Banks, ebiz news from Japan http://www.japaninc.com/tt450
22. Helene Meyer Tvinnereim. Moba Tann – A BioBank for the future. International Workshop: Bergen, Norway, 2008.
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