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Original Research

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Congenital Granular Cell Lesion: Clinical, Microscopic and Immunohistochemical Aspects in a Case of Multiple Lesions

  • José Humberto Damante1
  • Elen de Souza Tolentino1,*,
  • Reinaldo Mazzottini2
  • Flávio Monteiro-Amado3
  • Raul Negrão Fleury4
  • Cleverson Teixeira Soares4

1Department of Oral Medicine, Bauru Dental School, University of São Paulo, Bauru

2Maxilofacial surgeon at Craniofacial Anomalies Rehabilitation Hospital, Bauru

3Implantology at Craniofacial Anomalies Rehabilitation Hospital, Bauru

4Lauro de Souza Lima Institute, Bauru

DOI: 10.17796/jcpd.36.1.y1x9526472206504 Vol.36,Issue 1,September 2011 pp.71-74

Published: 01 September 2011

*Corresponding Author(s): Elen de Souza Tolentino E-mail: elen_tolentino@hotmail.com

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Abstract

Congenital granular cell lesion of the newborn, also known as congenital epulis, is a rare benign oral cavity tumor presenting at birth. Usually, it appears as a solitary mass arising in the mouth and originates from the anterior alveolar ridge. The objective of the present article is to report a case of congenital granular cell lesion in an 8-day-old female newborn. The patient presented four intraoral pedunculated lesions. Diagnosis, treatment, microscopic and immunohistochemical characteristics are also discussed.

Keywords

Congenital epulis; Granular cells lesion; Newborn diseases; Minimally invasive surgical procedures

Cite and Share

José Humberto Damante,Elen de Souza Tolentino,Reinaldo Mazzottini,Flávio Monteiro-Amado,Raul Negrão Fleury,Cleverson Teixeira Soares. Congenital Granular Cell Lesion: Clinical, Microscopic and Immunohistochemical Aspects in a Case of Multiple Lesions. Journal of Clinical Pediatric Dentistry. 2011. 36(1);71-74.

URL:

https://www.jjocpd.com/articles/10.17796/jcpd.36.1.y1x9526472206504

References

1. Olson JL, Marcus JR, Zuker RM. Congenital epulis. J Craniofac Surg, 16:161–4, 2005.

2. Nakata M, Anno K, Matsumori LT, et al. Prenatal diagnosis of conge-nital epulis: a case report. Ultrasound Obstet Gynecol, 20: 627–9, 2002.

3. McGuire TP, Gomes PP, Freilich MM, Sandor GK. Congenital epulis: a surprise in the neonate. J Can Dent Assoc, 72: 747–50, 2006.

4. Neumann E, Elin Fall von. Congenitaler Epulis. Arch Heilk, 12: 189, 1871

5. Laco J. Congenital granular cell epulis: a case report. Cesk Patol, 45(4): 117–9, 2009.

6. Merrett  SJ,  Crawford  PJ.  Congenital  Epulis  of  the  Newborn:  a  case report. Int J Paediatr Dent, 13(2): 127–9, 2003.

7. Bilen BT, Alaybeyoglu N, Arslan A, et al. Obstructive congenital gin-gival granular cell tumour. Int J Pediatr Otorhinolaryngol, 68: 1567–71, 2004.

8. Song WS,  Kim  JW,  Kim YG,  Ryu  DM. A  case  report  of  congenital epulis in the fetus. J Oral Maxillfac Surg, 63: 135–7, 2005.

9. Loyola AM, Gatti AF, Santos Pinto JR D, Mesquita A. Alveolar and extra-alveolar grannular cell lesions of the newborn: report of case and review of literature. Oral Surg Oral med Pra Pathol Oral Radiol Endod, 84: 668–71, 1997.

10. Tokar B, Boneval C, Mirapoglu S, et al. Congenital granular-cell tumor of the gingiva. Pediatr Surg Int, 13: 594–6, 1998.

11. Takeda Y, Satoh M, Nakamura S, Matsumoto D. Congenital leiomy-omatous epulis: A case report with immunohistochemical study. Pathol Int, 50: 999–1002, 2000.

12. Le  BH,  Boyer  PJ,  Lewis  JE,  Kapadia  SB.  Granular  Cell  Tumor: Immunohistochemical Assessment of Inhibin-a, Protein Gene Product 9.5, S100 Protein, CD68, and Ki-67 Proliferative Index with Clinical Correlation. Arch Pathol Lab Med, 128: 771–5, 2004.

13. Senoo  H,  Iida  S,  Kishino  M,  et  al.  Solitary  congenital  granular  cell lesion  of  the  tongue.  Oral  Surg  Oral  Med  Oral  Pathol  Oral  Radiol Endod, 104:e45–e48, 2007.

14. Guven S, Kaymakci A, Bugday MS, Yilmaz M. Congenital Granular Cell Tumor. J Craniofac Surg, 20(3): 976–7, 2009.

15. Küpers AM, Andriessen P, van Kempen MJP, et al. Congenital epulis of the jaw: a series of five cases and review of literature. Pediatr Surg Int, 25: 207–10, 2009.

16. Fister P, Volavsek M, Server N, Jazbec J. A newborn baby with a tumor protruding  from  the  mouth.  Acta  dermatoven  APA,  16(3):  128–30, 2007.

17. Witman PM, Rogers RS. Pediatric oral medicine. Dermatol Clin, 21(1): 157–70, 2003.

18. Shaw L, Al-Malt A, Carlan SJ, et al. Congenital epulis: three-dimen-sional ultrasonographic findings and clinical implications. J Ultrasound Med, 23: 1121–4, 2004

19. Abbo O, Breibach F, Vaysse F, et al. Antenatal diagnosis of a congeni-tal granular cell tumor. Rev Stomatol Chir Maxillofac, 111: 91–3, 2010.

20. Parmigiani S, Giordano G, Fellegara G, et al. A rare case of multiple congenital  epulis.  J  Matern  Fetal  Neonatal  Med,  16  Suppl  2:55–8, 2004.

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