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Original Research

Open Access

Cyclic Neutropenia Presenting as Recurrent Oral Ulcers and Periodontitis

  • Chen Y1
  • Fang L1
  • Yang X1,*,

1Hospital of Stomatology, School of Medicine, Zhejiang University, 395# Yan’ an Road, Hangzhou 310006, China.

DOI: 10.17796/jcpd.37.3.n8k0111177074828 Vol.37,Issue 3,May 2013 pp.307-308

Published: 01 May 2013

*Corresponding Author(s): Yang X E-mail: happypeer@hotmail.com

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Abstract

Cyclic neutropenia (CN) is a rare congenital disease that can present with recurrent oral ulcers and periodontitis. CN can easily be misdiagnosed as major recurrent aphthous stomatitis (MaRAS) or aggressive periodontitis (AP) in dental clinics. We describe the case of an 8-year-old boy with CN, and compare the oral manifestations of CN with those of MaRAS and AP. Case report: An 8-year-old boy presented with a history of recurrent oral ulcers, periodontal destruction, pharyngitis and otitis media since the age of 3 months. Repeated, routine blood tests showed 1-week-long neutropenic periods that occurred at intervals of 2 weeks. A bone marrow cytology test during a neutropenic period demonstrated a decrease in granulocyte count. During a 2-year follow-up, his symptoms were well controlled by regular administration of granulocyte colony-stimulating factor and periodontal maintenance. Conclusion: Several clinical features help to differentiate CN from MaRAS and AP. Early recognition of the systemic cause of oral symptoms is important.

Keywords

Cyclic neutropenia, Oral ulcers, Periodontal destruction.

Cite and Share

Chen Y, Fang L,Yang X. Cyclic Neutropenia Presenting as Recurrent Oral Ulcers and Periodontitis. Journal of Clinical Pediatric Dentistry. 2013. 37(3);307-308.

URL:

https://www.jocpd.com/articles/10.17796/jcpd.37.3.n8k0111177074828

References

1. Boxer L, Dale DC. Neutropenia: causes and consequences. Semin Hematol 39: 75-81, 2002.

2. Matarasso S, Daniele V, Iorio Siciliano V, et al. The effect of recombinant granulocyte colony-stimulating factor on oral and periodontal manifestations in a patient with cyclic neutropenia: a case report. Int J Dent; 26: 236-239, 2009.

3. Nakai, Y., Ishihara, C., Ogata, S. & Shimono, T. Oral manifestations of cyclic neutropenia in a Japanese child: case report with a 5-year follow-up. Pediatr Dent;25: 383-388, 2003.

4. Rogers RS 3rd. Recurrent aphthous stomatitis: clinical characteristics and associated systemic disorders. Semin Cutan Med Surg; 16: 278-83, 1997. 5. Highfield J. Diagnosis and classification of periodontal disease. Aust Dent J; 54S1: S11-26, 2009.

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