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Original Research

Open Access

Prevalence and Characteristics of Non-Syndromic Orofacial Clefts and the Influence of Consanguinity

  • Alamoudi NM1,*,
  • Sabbagh H J1
  • Innes NPT2
  • El Derwi D1
  • Hanno AZ1
  • Al-Aama JY1
  • Habiballah A H1
  • Mossey P A2

1Preventive Dental Sciences Department, Faculty of Dentistry, King Abdulaziz University, Kingdom of Saudi Arabia

2University of Dundee University Dental School 1Park Place Dundee, DD1 4HR Scotland, UK.

DOI: 10.17796/jcpd.38.3.bm4m2158v17p2535 Vol.38,Issue 3,April 2014 pp.241-246

Published: 01 April 2014

*Corresponding Author(s): Alamoudi NM E-mail: nalamoudi2011@gmail.com

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Abstract

The Objective of this study was to identify the prevalence and describe the characteristics of non-syndromic orofacial cleft (NSOFC) in Jeddah, Saudi Arabia and examine the influence of consanguinity. Study Design: Six hospitals were selected to represent Jeddah’s five municipal districts. New born infants with NSOFC born between 1st of January 2010 to 31st of December 2011 were clinically examined and their number compared to the total number of infants born in these hospitals to calculate the prevalence of NSOFC types and sub-phenotypes. Referred Infants were included for the purpose of studying NSOFC characteristics and their relationship to consanguinity. Information on NSOFC infants was gathered through parents’ interviews, infants’ files and patient examinations. Results: Prospective surveillance of births resulted in identifying 37 NSOFC infants born between 1st of January 2010 to 31st of December 2011 giving a birth prevalence of 0.80/1000 living births. The total infants seen, including referred cases, were 79 children. Consanguinity among parents of cleft palate (CP) cases was statistically higher than that among cleft lip with or without cleft palate (CL/P) patients (P=0.039). Although there appears to be a trend in the relationship between consanguinity and severity of CL/P sub-phenotype, it was not statistically significant (P= 0.248). Conclusions: Birth prevalence of NSOFC in Jeddah City was 0.8/1000 live births with CL/P: 0.68/1000 and CP: 0.13/1000. Both figures were low compared to the global birth prevalence (NSOFC: 1.25/1000, CL/P: 0.94/1000 and CP: 0.31/1000 live births). Consanguineous parents were statistically higher among CP cases than among other NSOFC phenotypes.

Keywords

Prevalence, Saudi Arabia, cleft lip, Cleft palate, orofacial cleft, consanguinity

Cite and Share

Alamoudi NM,Sabbagh H J,Innes NPT,El Derwi D,Hanno AZ,Al-Aama JY,Habiballah A H,Mossey P A. Prevalence and Characteristics of Non-Syndromic Orofacial Clefts and the Influence of Consanguinity. Journal of Clinical Pediatric Dentistry. 2014. 38(3);241-246.

URL:

https://www.jocpd.com/articles/10.17796/jcpd.38.3.bm4m2158v17p2535

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